Effective Interventions

Effective Interventions

High Impact Prevention

¡Cuídate!, which means "take care of yourself," is a culturally-based, group-level intervention to reduce HIV sexual risk behavior among Latino youth. It is based on Social Cognitive Theory, Theory of Reasoned Action, and Theory of Planned Behavior, and incorporates cultural beliefs that are common among Latino subgroups and associated with sexual risk behavior

¡Cuídate!¡Cuídate! consists of six 1-hour modules delivered over a minimum of 2 days to groups of 6 to 10 youth. ¡Cuídate! can be delivered in community centers, schools, etc. by health educators, counselors, health care providers, etc. HIV/AIDS knowledge, condom negotiation, refusal of sex, and correct condom use skills are taught through interactive games, group discussion, role-plays, video, music, and mini-lectures.

¡Cuídate! targets Spanish and non-Spanish speaking Latino youth, ages 13 to 18.

Important CDC Update: 

The CDC’s strategy for High Impact HIV Prevention involves prioritizing and implementing an optimal combination of cost-effective, scalable interventions based on the current state of the science.  This shift should help improve the effectiveness of HIV prevention efforts, reduce HIV incidence, and ultimately increase the possibility of achieving an AIDS-free America.  In its ongoing effort to align HIV prevention resources with current surveillance data and this strategy, the Division of HIV/AIDS Prevention (DHAP) at CDC will not offer trainings or capacity building assistance on the following evidence-based interventions (EBIs): AIM, ¡Cuídate!, Focus on Youth, MIP, Nia, RAPP, Safety Counts, SHIELD, SIHLE, SISTA, Street Smart, RESPECT and VOICES/VOCES (except when used with MSM). The Division also will not offer trainings or capacity building assistance on some new EBIs, such as Healthy Love. Health departments or other funders may continue to support implementation of these EBIs, and the implementation materials for all these interventions will remain on this site and be available for download. If you have additional questions about this issue, please contact interventions@danya.com.

CDC’s Division of Reproductive Health (DRH) will provide support to their grantees on AIM, ¡Cuídate!, and SIHLE. For further information on DRH’s efforts, please contact Trisha Mueller at czj5@cdc.gov

How to request ¡Cuídate! training and technical assistance

As mentioned above, CDC no longer offers ¡Cuídate! training support unless you are a CDC Division of Reproductive Health (DRH) grantee. If you are seeking ¡Cuídate! training, you may consider contacting the University of Michigan - School of Nursing/Division of Health Promotion and Risk Reduction Programs to request free online training through Second Life. Second Life is a web-based environment where participants have the opportunity to learn and practice the skills needed to implement ¡Cuídate!. The training is provided by Dr. Villarruel, a developer of the ¡Cuídate! curriculum along with other experienced ¡Cuídate! trainers. To be eligible to participate in the training program:

  • Have access to a computer that will be used throughout the entire program
  • High-speed internet access
  • Commitment to participate in 3 Second Life training sessions, as well as other web-based training-related activities
  • Commit to implementing the program curriculum with adolescents at least twice within 6 months of completing the training 
To learn more about this training program, including how to register for July - October 2013 training sessions, please visit www.cuidate.nursing,umich.edu. You may also download a printer friendly version of the ¡Cuídate! training announcement

Research and Development

Villarruel, A.M., Jemmott, J.B. III, and Jemmott, L.S. (2006). A randomized controlled trial testing an HIV prevention intervention for Latino youth. Archives of Pediatric & Adolescent Medicine, 160, 772-777.

Gallegos, E.C., Villarruel, A.M., Loveland-Cherry, C., Ronis, D.L., and Zhou, Y. (2008). Intervención para reducir riesgo en conductas sexuales de adolescents: Un ensayo aleatorizado y controlado [Intervention to reduce sexual risk behavior in adolescents: A randomized controlled trial]. Salud Pública de México, 50(1): 59-66.

Program Review Panel Information

The CDC requires all CDC-funded agencies using the ¡Cuídate! intervention to identify, or establish, and utilize a Program Review Panel and complete Form 0.1113 to document this activity. The intervention researchers and developers are not involved in this activity. This is a CDC requirement for their grantees, and all questions in this regard should be directed to your agency's CDC Project Officer or to the health department funding your agency's implementation of the intervention.

The Program Review Panel guidelines, instructions for completion of Form 0.113, and the form itself are available under the Related Links section of the this website.

CDC Policy on Youth Peer Outreach Workers


CDC funded (directly or indirectly) agencies using youth (either paid or volunteer) in program outreach activities need to use caution and judgment in the venues/situations where youth workers are placed. Agencies should give careful consideration to the "age appropriateness" of the activity or venue. Additionally, agencies should comply with all relevant laws and regulations regarding entrance into adult establishments/environments. Laws and curfews should be clearly outlined in required safety protocols developed and implemented by agencies directly and indirectly funded by CDC.

If you have specific questions, please contact your CDC project officer.

More Info

¡Cuídate! Core Elements

  • Incorporating the theme of ¡Cuídate!—taking care of oneself and one’s partner, family and community— throughout the program.
  • Using culturally- and linguistically-appropriate materials and activities to show and emphasize core Latino cultural values, specifically familialism and gender-roles, and how those are consistent with safer sex behavior.
  • Incorporating activities that increase knowledge and influence positive attitudes, beliefs, and self-efficacy regarding HIV sexual risk-reduction behaviors.
  • Modeling and practicing the effective use of condoms. 
  • Building participants' skills in problem solving, negotiation of safe sex, and refusal of unsafe sex.
  • Delivering sessions in highly participatory, interactive small groups. 

Technical Assistance

The materials on this site are designed for HIV/AIDS prevention with persons at risk for acquiring or transmitting HIV. They are meant to be resources used by HIV prevention providers such as health departments and community-based organizations so as to provide the best evidence-based HIV prevention services. These materials are not meant for the general public. They are not meant for children. They are not school-based HIV prevention strategies.