Effective Interventions

Effective Interventions

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A New Medication Adherence e-Learning Training Toolkit for Providers

Every Dose Every Day is designed to help providers support medication adherence among people living with HIV to improve the health outcomes and increase the prevention benefits of treatment. 

Every Dose Every Day (E2D2) Mobile App (New Version)


The redesigned CDC Every Dose Every Day mobile app is now available for Apple and Android smartphones! iOS and Android users can set dose and medical appointment reminders, track labs, share adherence progress with their medical team, and more. The app may also be helpful with improving adherence to pre-exposure prophylaxis (PrEP). Download the free app today.

To download the Every Dose Every Day App, visit the App Store or Google play Store. To learn more about the App and the (4) E2D2 eLearning Modules, view below.  


Adherence to anti-retroviral therapy (ART) is critical to the success of HIV treatment and treatment as prevention. However, the benefits of ART can be realized only by those individuals who are tested, diagnosed, timely linked to medical care, and start and adhere to ART to achieve viral suppression.

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Audio Description video: MP4 format

Development of the 4 Medication Adherence Strategies approved for e-Learning Courses

In April 2011, eight individual and group-level evidence-based strategies to support HIV medication adherence were reviewed and identified as “good-evidence” by the Centers for Disease Control & Prevention (CDC) Prevention Research Synthesis Project's Compendium of Evidence-Based Interventions and Best Practices for HIV Prevention. The Capacity Building Branch selected four of the eight medication adherence strategies to be translated into an
e-learning training toolkit for clinical and non-clinical HIV providers who serve persons living with HIV (PLWH). The 4 adherence strategies can be delivered by a variety of HIV providers, including medical providers, licensed social workers, HIV case managers, health educators and/or peers.

The Every Dose Every Day e-Learning Training Toolkit features four evidence-based strategies: 

  • HEART (CE# WB2257) - Individual/dyadic, social support and problem-solving intervention delivered before and in the first two months after initiating ART, includes a patient-identified support partner
  • SMART Couples (CE# WB2258) - Discordant couple-level intervention, addresses ART adherence and safer sex practices within the dyad, by fostering active support between partners
  • Peer Support (CE# WB2259) - Individual-and group-level intervention, where HIV-positive people, currently adherent to ART, serve as peers and provide medication-related social support
  • Partnership for Health for Medication Adherence (CE# WB2260) - Individual-level, clinic-based, brief provider-administered intervention emphasizes the importance of the patient-provider relationship to promote adherence
The toolkit also includes:
  • Mobile Application for iOS and Android smartphones featuring dose reminders and pharmacy refills - AVAILABLE. See below for more info. 
  • Consumer handouts about the importance of staying adherent and understanding viral load and CD4 count
  • Posters featuring real persons living with HIV and their reason for staying adherent
  • Program Monitoring Companion in this document you can find the general information on program monitoring: what it is, how to do it and program monitoring questions that the CDC considers high priority. These questions will be used as examples throughout this document to illustrate how HIV care providers can collect and use data to monitor your program, improve delivery of ART adherence interventions, and ultimately reduce the impact of HIV on individuals and society. The tools for monitoring your program and interpreting your data includes information on outcomes, individual-level and program-level data collection templates, and case studies demonstrating use of program monitoring questions.

The interactive and media rich e-Learning training will include the following topics:

  • Benefits of ART adherence
  • Components of each adherence strategy
  • Key players and staff roles and responsibilities
  • Overview of session content
  • Strategy in action (e.g., videos of sessions)
  • Integrating the strategy into practice
  • Additional resources (e.g., downloadable comprehensive implementation materials, consumer materials conveying the importance of adherence, and information about requesting technical assistance and capacity building)

To register for the four Medication Adherence e-Learning trainings, visit the HIP e-Learning Center.

HIP e-Learning Center Logo 

Every Dose Every Day Mobile Application

The EVERY DOSE EVERY DAY (E2D2) mobile application (app) builds on the Pager Messaging intervention by assisting people living with HIV with dose, refill, and medical appointment reminders. Additionally, the app features lab tracking (e.g., viral load and CD4 count) to help the user understand how their HIV treatment regimen supports better health. The user may input important contact information of their health care team. There is also a feature that allows the user to upload a “Reason Photo”, which can serve as an inspirational reminder of why taking your HIV medication every day is important. The user may log reasons for missing a dose and information about a particular dose in the “dose notes” feature for their medications. Dose notes may include information about side effects or whether a medication needs to be taken with or without food. This information may be useful in discussing adherence challenges with their medical provider. The mobile app can be used alone or in combination with any of the 4 medication adherence strategies.
To download the Every Dose Every Day App, visit the App Store or Google play Store.


For additional information on CDC’s medication adherence strategies, please see the Compendium of Evidence-Based HIV Behavioral Interventions: Medication Adherence Chapter.

The materials on this site are designed for HIV/AIDS prevention with persons at risk for acquiring or transmitting HIV. They are meant to be resources used by HIV prevention providers such as health departments and community-based organizations so as to provide the best evidence-based HIV prevention services. These materials are not meant for the general public. They are not meant for children. They are not school-based HIV prevention strategies.